|
KMID : 0365819710110010197
|
|
Journal of Pusan Medical College
1971 Volume.11 No. 1 p.197 ~ p.204
|
|
|
An Experimental Study on the Drug Therapy of Acute Carbon Monoxide Poisoning
|
|
|
|
|
Abstract
|
|
|
Carbon Monoxide poisoning is one of the most serious medical problems in Korea because of its remarkably higher incidence. It has been known that the treatment of choice for this poisoning is the inhalation of pure oxygen as soon as possible. Recent study has revealed that the inhalation of pure oxygen under pressure, so called hyperbaric oxygenation, has a dramatic effects in the treatment of C4 poisoning.
But our situation does not allow us to send every CO poisoning patients to hyperbaric chamber unit because of the rarity of this facility in Korea. The necessity of studying effective therapeutic drugs still maintains vlaue in the clinical view of point in our country.
Author performed this- study to find out most effective therapeutic drugs. Cytochrome C, lodoacetate, Succinic Acid, Co-Carboxylase and Ascorbic Acid were selected.
The following findings were obtained.
1. The administration of Cytochrome C and Succinic Acid enhanced the tolerance of rat to CO poisoning, but lodoacetate reduced the tolerance of rat. Co-Carboxylase and Ascorbic Acid did´nt show any influence as far as the tolerance is concerned.
2. The administration of Cytochrome C and Succinic Acid showed marked therapeutic effectiveness by shortening the recovery time and reducing fatality rate. Co-Carboxylase also showed some therapeutic effectiveness. No therapeutic effectiveness was found in the administration of lodoacetate and Ascorbic Acid
3. Organ-body weight ratio was measured in each experimental groups. This ratio has proved as a reliable macro-pathological index, especially in extrapolating therapeutic effectiveness of the experimental drugs.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|